In organic chemistry, phosphonates or phosphonic acids are organophosphorus compounds containing C−PO(OR)2 groups (where R = alkyl, aryl, or just hydrogen). Phosphonic acids, typically handled as salts, are generally nonvolatile solids that are poorly soluble in organic solvents, but soluble in water and … See more Phosphonates feature tetrahedral phosphorus centers. They are structurally closely related to (and often prepared from) phosphorous acid. Phosphonate salts are the result of deprotonation of … See more Bisphosphonates Compounds containing 2 geminal phosphonate groups are known as bisphosphonates. They were first synthesized in 1897 by Von Baeyer and Hofmann and now form the basis for an important class of … See more In 1998 the consumption of phosphonates was 56,000 tons worldwide – 40,000 tons in the US, 15,000 tons in Europe and less than 800 tons in Japan. The demand of phosphonates grows steadily at 3% annually. Metal chelants See more Several methods exist for the preparation of phosphonic acids and their salts. From phosphonic acid Most processes … See more Hydrolysis Phosphonate esters are generally susceptible to hydrolysis under both acidic and basic conditions. Cleavage of the P-C bond is harder but can be achieved under aggressive conditions. O=PC(OR)2 + 2 H2O … See more Phosphonates are one of the three sources of phosphate intake in biological cells. The other two are inorganic phosphate and organophosphates. The naturally occurring phosphonate 2-aminoethylphosphonic acid was first identified in 1959 in … See more In medicine, phosphonates and bisphosphonates are commonly used as inhibitors of enzymes which utilize phosphates and … See more WebTenofovir disoproxil is a pro-drug form of tenofovir phosphonate, which is liberated intracellularly and converted to tenofovir disphophate. [29] It is marketed by Gilead Sciences (as the fumarate, abbreviated TDF). [30] Tenofovir disoproxil is also available in pills which combine a number of antiviral drugs into a single dose.
Phosphonsäuren – Wikipedia
WebPhosphonates are one of the three sources of phosphate intake in biological cells. [citation needed] The other two are inorganic phosphate and organophosphates. The naturally … WebDie Bisphosphonate sind Ester und Salze der Methylendiphosphonsäure (Medronsäure). Sie sind Diphosphat - Analoga, in denen der Sauerstoff der P–O–P-Bindung durch Kohlenstoff ersetzt ist. Verbindungen dieses Typs zählen zu den Phosphonaten. Sie unterliegen im Körper keiner enzymatischen Hydrolyse. floral print bow ties
Composé organophosphoré — Wikipédia
WebPhosphonates or Phosphonic acids are organic compounds containing one or more C-PO (OH) 2 or C-PO (OR) 2 (with R= alkyl, aryl) groups. Bisphosphonates were first synthesized in 1897 by Von Baeyer and Hofmann. An example of such a bisphosphonate is HEDP. Webdiethyl 4-methyl benzyl phosphonate. Application. Reactant involved in: • Synthesis of stilbenes via oxidation and Horner-Emmons reactions. • Intramolecular cyclization of aryl ethers, amines, and amides. • Studies of the effects of functional groups on the performance of blue organic LEDs. • Olefination reactions. WebL' ion phosphate (ou orthophosphate) est un anion polyatomique de formule chimique brute P O 43− et de masse moléculaire de 94,97 daltons. Il se présente sous la forme d'un tétraèdre dont les sommets sont formés par les quatre atomes d' oxygène encadrant un atome de phosphore . floral print bow tie