WebTheoretical Studies Toward the Asymmetric Lithiation of N-containing Heterocycles Understanding the Origin of Selectivity in the Asymmetric Lithiation Reaction of N-Heterocycles: A Theoretical Study Keivan Taban, M.Sc. M.Sc. Chemistry Submitted in partial fulfillment of the requirement for the degree of Master of Science WebFor heterocycles alkyl lithium bases are used as well as lithium amides. Solvent choices for these lithiations are usually ether or THF. TMEDA or HMPA are often added as …
Directed lithiation of simple aromatics and heterocycles for …
WebDirected lithiation of substituted aromatics and heterocycles containing a directing metalating group with alkyllithium in anhydrous tetrahydrofuran or diethyl ether at … Web23 mei 2024 · On the basis of the double-lithiation strategy, two novel synthetic methodologies have been developed under mild reaction conditions (room temperature): (1) reactions of lithiated thioanisoles with nitriles give benzoisothiazoles via a [3 + 2]-type of approach with two new bond formations and (2) formation of benzothiophenes from … open university kandy contact number
Directed lithiation of simple aromatics and heterocycles for …
Web1 jan. 2011 · Heterocyclic compounds are of immense importance in many fields of chemistry in particular and science in general. Numerous applications of heterocyclic compounds have been reported, for example, as pharmaceuticals, agrochemicals, organic materials, and many more [1–3].Hence, the synthesis of heterocycles and more … Web25 okt. 2024 · This review covers the enantioselective lithiation–substitution at the α-position of nitrogen-containing heterocycles mediated by strong organolithium bases … Web2.3 High Temperature Lithiation-trapping of N-Boc N'-benzyl Piperazine 55 2.4 High Temperature Lithiation-trapping of N-Boc Piperidine and N-Boc Azepane 60 2.5 Conclusions and Future Work 64 Chapter 3: Lithiation-trapping of Oxygen Heterocycles 66 3.1 Overview of Routes for the Generation and α-Functionalisation of Cyclic Ethers 67 ipc worcestershire