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Hif-1 alpha protein

Web3 de jul. de 2003 · Endothelial PAS domain-containing protein 1. Gene. EPAS1. Status. UniProtKB reviewed (Swiss-Prot) Organism. Homo sapiens (Human) Amino acids. 870. Protein existence. Evidence at protein ... Hypoxia-inducible factor 2-alpha (HIF-2-alpha; HIF2-alpha) Member of PAS protein 2; PAS domain-containing protein 2; Gene names. … WebThis antibody does not cross-react with ARNT or the related HIF-2 alpha. MA1-516 has been successfully used in Western blot, immunofluorescence, immunoprecipitation, immunocytochemistry, and gel shift procedures. By Western blot, this antibody detects an ∽116 kDa protein representing HIF-1 alpha after hypoxic induction in COS cells.

HIF1A Monoclonal Antibody (mgc3), Invitrogen™

Webアズワンの【AXEL】84-1432-35 HIF1A (Hypoxia-inducible Factor 1-alpha, HIF-1-alpha, HIF1-alpha, ARNT-interacting Protein, Basic-helix-loop-helix-PAS Protein MOP1, Class … WebSummary of HIF1A (bHLHe78, HIF-1alpha, HIF1, MOP1, PASD8) expression in human tissue. Mainly nuclear expression with cases of cytoplasmic expression. ... Hypoxia … sidewinder chair ashley furniture https://riflessiacconciature.com

HIF1A Gene - GeneCards HIF1A Protein HIF1A Antibody

WebUnder hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate … Induces stabilization of the protein. 1 publication. Sequence: S → A: … We'd like to inform you that we have updated our Privacy Notice to comply … UniRef - UniProt History - UniProt External Links - UniProt Gostaríamos de exibir a descriçãoaqui, mas o site que você está não nos permite. Induces stabilization of the protein. 1 publication. Sequence: S → A: … YTH domain-containing protein 1 · Gene: YTHDC1 (KIAA1966, YT521) · Homo … WebA loss of signal was observed for target protein in HIF-1 alpha KO cell line compared to control cell lines using ab16066. Uncharacterized bands were observed in HeLa Cas9 samples at ~40 kDa and 45 kDa. Protocols. Nuclear Extract Preparation for HIF 1 alpha. Click here to view the general protocols. WebHIF-1 is a heterodimer formed by the association of a constitutively expressed HIF-1 beta subunit and a HIF-1 alpha subunit, the expression of which is highly regulated. In this study, pharmacologic concentrations of melatonin was found to inhibit expression of HIF-1 alpha protein under both normoxic and hypoxic conditions in DU145, PC-3, and LNCaP … sidewinder chain and sprockets

HIF-1 alpha protein as a target for S-nitrosation - PubMed

Category:RCSB PDB - 4ZPR: Crystal Structure of the Heterodimeric HIF …

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Hif-1 alpha protein

Hypoxia-inducible factor 1-alpha (human) Protein Target

Web21 de mar. de 2024 · The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, … Web11 de abr. de 2024 · The elevations in HIF-1α and HIF-2α protein levels indicated that hypoxia reactions were successfully induced by CoCl 2 and 1% O 2 treatment (Figure 1C,D). ATX induction was also observed in human colon cancer DLD1 and Hela cells treated with CoCl 2 or cultured under hypoxic conditions (1% O 2 ) ( Figure S1 ).

Hif-1 alpha protein

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Web3 de ago. de 2024 · Some studies have clarified the role of HIF-1α in the pathogenesis of viral hepatitis, mainly with regard to hepatitis B and C. Hepatitis B virus (HBV) encodes the viral tumor protein transactivator protein X (HBx), which promotes extracellular matrix modification through the HIF/LOX pathway in liver cancer , and HBx mutation affects the … WebProtein target information for Hypoxia-inducible factor 1-alpha (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

WebThis gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer c omposed of an alpha and a beta subunit. HIF-1 functions as … WebCommon gene targets for HIF-1 and HIF-2 include VEGFA and GLUT1 (5). The HIF-2 alpha subunit is rapidly targeted and degraded by the ubiquitin proteasome system under normoxic conditions. This process is mediated by oxygen-sensing enzymes, prolyl hydroxylase domain enzymes (PHDs), which catalyze the hydroxylation of key proline …

WebThis antibody does not cross-react with ARNT or the related HIF-2 alpha. MA1-516 has been successfully used in Western blot, immunofluorescence, immunoprecipitation, … Web30 de jan. de 2003 · HIF-1 alpha stability regulation initiates a complex biological response that allows cells to act appropriately to meet patho-physiological situations of decreased …

Web12 de ago. de 2002 · 1H2K, 1H2L, 1H2M, 1H2N. PubMed Abstract: The activity of the transcription factor hypoxia-inducible factor (HIF) is regulated by oxygen-dependent hydroxylation. Under normoxic conditions, …

Web9 de mai. de 2002 · HIF-1 alpha is the oxygen-regulated subunit of HIF-1, an alpha beta heterodimeric complex. HIF-1 alpha is stable in hypoxia, but in the presence of oxygen it … the pointe apartments clearwater flWebHIF1A, hypoxia inducible factor 1 subunit alpha Synonyms bHLHe78, HIF1, HIF-1A, HIF-1alpha, HIF-1-alpha, HIF1-ALPHA, MOP1, PASD8 the pointe apartments jmuWebNational Center for Biotechnology Information the pointe apartments lewisvilleWeb1 de fev. de 2004 · Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian … sidewinder cocktailWebHIF1-alpha (HIF1A) is a subunit of HIF1, which is a transcription factor found in mammalian cells cultured under reduced oxygen tension. HIF-1 is a heterodimer consisting of an alpha and beta subunit, both belonging to the basic-helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator-Sim (PAS) family of transcription factors. the pointe apartments in joppa mdWebFigure 1 Up-regulation of ASAP3 is associated with lung adenocarcinoma. (A) Levels of ASAP3 mRNA in human lung adenocarcinoma tissues and matched adjacent non-neoplastic tissues.(B and C) Western blot analysis of ASAP3 protein levels in three pairs of human lung adenocarcinoma tissues and matched adjacent non-tumorous tissues.ASAP3 … sidewinder circastleWeb9 de dez. de 2014 · HIF-1 alpha contained in a nuclear extract, binds specifically to the HIF-1 alpha response element. The HIF transcription factor complex is detected by addition of a specific primary antibody directed against HIF-1 alpha. A secondary antibody conjugated to HRP is added to provide a sensitive colorimetric readout at 450 nm. sidewinder chemical pump