WebAug 14, 2024 · The kinetochore is a complex macromolecular structure, comprising of more than 100 different proteins, that assembles at the centromere of each chromosome during cell division 1,2.Kinetochores ... WebApr 12, 2024 · what: The authors report two modifications on the centromeric histone H3 variant CENP-A/Cse4 in the yeast Saccharomyces cerevisiae methylation at arginine 143 (R143me) and lysine 131 (K131me) that affect centromere stability and kinetochore function. Altogether, the authors propose that the absence of Cse4-R143me and …
Four new subunits of the Dam1–Duo1 complex reveal novel functions …
WebAug 26, 2024 · Centromere integrity underlies an essential framework for precise chromosome segregation and epigenetic inheritance. Although centromeric DNA sequences vary among different organisms, all eukaryotic centromeres comprise a centromere-specific histone H3 variant, centromeric protein A (CENP-A), on which other centromeric … WebOct 30, 2001 · Microtubule-binding proteins function at the kinetochore to mediate at least three vital activities: chromosome attachment to the spindle, coordination with the spindle assembly checkpoint, and poleward chromosome movement during anaphase. At least 30 proteins have already been identified to function at the kinetochore in budding yeast, … cutaneous ocular toxicology journal
A new mechanism controlling kinetochore–microtubule …
WebThe vertebrate kinetochore is a complex structure that specifies the attachments between the chromosomes and microtubules of the spindle and is thus essential for accurate chromosome segregation. Kinetochores are assembled on centromeric chromatin through complex pathways that are coordinated with the cell cycle. In the light of recent … WebJul 25, 2024 · Kinetochore protein phosphorylation promotes the correction of erroneous microtubule attachments to ensure faithful … WebSep 1, 2024 · The kinetochore plays an essential role in facilitating chromosome segregation during cell division. This massive protein complex assembles onto the centromere of chromosomes and enables their attachment to … cutaneous pathology associates