Cyp24a1酶
WebPROTEIN SUMMARY SECTION OVERVIEW RNA DATA ANTIBODY DATA. CYP24A1 INFORMATION. Proteini. Full gene name according to HGNC. Cytochrome P450 family 24 subfamily A member 1. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. CYP24A1 (CP24, CYP24, P450-CC24) Protein classi. WebApr 12, 2024 · 3-羟基3-甲基戊二酰辅酶A还原酶(HMGCR)重组蛋白说明书. Recombinant 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (HMGCR) [ PROPERTIES ] Source: Prokaryotic expression. Host: E. coli. Residues: Ala638~Ala887. Tags: N-terminal His-Tag. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane. protein. …
Cyp24a1酶
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Web25-羟维生素D3-24-羟基化酶 (CYP24A1)是使1α,25-二羟基维生素D3 (1α,25 (OH)2D3)和25-羟基维生素D3 (25 (OH)D3)代谢失活的关键酶.活性维生素D (1α,25 (OH)2D3)不仅能够 … WebApr 12, 2024 · The CYP24A1 gene encodes 1,25-hydroxyvitamin-D3-24-hydroxylase, a key enzyme responsible for the catabolism of active vitamin D (1,25-dihydroxyvitamin D3). Loss-of-function mutations in CYP24A1 …
Web细胞色素 P450 24A1（英語： Cytochrome P450 24A1 ，缩写CYP24A1）也被称为维生素D 3 24-羟化酶（ Vitamin D3 24-hydroxylase ，EC 1.14.15.16），是细胞色素P450超家族 …
WebJan 1, 2011 · CYP24A1 is a mitochondrial inner-membrane cytochrome P450 enzyme that exhibits multifunctionality: it is able to hydroxylate both the C23 or the C24 side-chain carbons of 25(OH)D or 1,25(OH) 2 D. The physiological relevance of these pathways has been confirmed in mice deficient for the Cyp24a1 gene. Recent work has focused on … WebA cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D 3) and the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D 3) (PubMed:24893882, PubMed:15574355, …
WebJan 1, 2024 · CYP24A1 is a mitochondrial inner-membrane cytochrome P450 enzyme that exhibits multifunctionality: it is able to hydroxylate both the C23 or the C24 side-chain …
WebDec 10, 2024 · Background and objectives: CYP24A1 encodes a 24-hydroxylase involved in vitamin D catabolism, whose loss-of-function results in vitamin D-dependent hypercalcemia. Since the identification of CYP24A1 variants as a cause of idiopathic infantile hypercalcemia, a large body of literature has emerged indicating heterogeneity in … kathleen ga in which countyWebLoss of function mutations in the CYP24A1 gene have been shown to lead to insufficient deactivation of bioactive vitamin D metabolites, resulting in a phenotype characterized by suppressed serum parathyroid hormone (PTH), increased serum 1,25-dihydroxyvitamin D (DHVD) concentrations, hypercalcemia, and hypercalciuria or nephrolithiasis. kathleen gallagher obituaryWebCYP24A1, encoding the vitamin D-24-hydroxylase, is of major clinical and physiologic importance, serving to regulate the catabolism of 1,25-(OH) 2 D, the physiologically active vitamin D metabolite. In addition to facilitating catabolism of 1,25-(OH) 2 D, CYP24A1 also enhances the turnover and elimination of 25-OHD, the abundant precursor metabolite … lay freezer down