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Web28 de out. de 2024 · No population pharmacokinetic studies of high-dose methotrexate (HDMTX) have been conducted in infants with brain tumours, which are a vulnerable population. The aim of this study was to evaluate HDMTX disposition in these children to provide a rational basis for MTX dosing. Web9 de set. de 2024 · This is consistent with our previous reports that systemic administration of BCP, at high doses (50, 100 mg/kg), also inhibits cocaine or nicotine self … flot oncology
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