WebFeb 16, 2024 · CTCF is thought to play a critical role in the formation of these loops, but the specificity of which CTCF binding events form loops and which do not is difficult to predict. Loops often have... WebJun 4, 2024 · In total, we found 12,116 CTCF BSs, among which only 363 were differential in CTCF binding between control and p63 mutant keratinocytes (p < 0.05), indicating that CTCF binding is rather stable. In …
Cooperation of ATF4 and CTCF promotes adipogenesis through
WebOct 8, 2012 · In conjunction with its phylogenetic distribution, these observations suggest that CTCF could play a role as an indispensable ( 31 – 33) genome organizer not only in D. melanogaster ( 27 ), humans ( 34 ), and mice ( 17 ), but also in protostomes and deuterostomes in general. WebTranscriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. [5] [6] CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V (D)J recombination [7] and regulation of chromatin architecture. [8] optima medicaid provider phone number
CTCF and Its Partners: Shaper of 3D Genome during Development
WebAug 24, 2024 · Background: The transcription factor CTCF appears indispensable in defining topologically associated domain boundaries and maintaining chromatin loop … WebJun 28, 2024 · CTCF is a unique regulator of gene expression, which can function as a transcriptional repressor and activator as well as a chromatin insulator, the latter occurring through interference of the contact between enhancers/silencers and promoters ( 5, 22 ). WebAug 25, 2024 · CTCF shows a genome-wide distribution of DNA occupancy, and 30–60% of its binding is cell type specific. 19 Although CTCF was first described as a transcription … portland me tourist attractions